The Michael Alan Nelson 'era' of Supergirl was over. The prior issue was part of a super-book crossover which gave the title a modest boost in sales. Tony Bedard and Yildiray Cinar were taking over the book, talking about a new direction, and discussing the book on lots of comic book sites. And the book starred the 'new' Lobo, a hot button character.
The Red Lantern announcement also was already out there when this book was published, an even newer direction for the book that was controversial.
Depending on your viewpoint, elements of the above list were either good news or bad news.
The question therefor is 'In regards to sales, did Supergirl #26 represent a jumping on point or a jumping off point?'
Interestingly enough, it looks like it was neither. Instead it was status quo. Supergirl #26 was ranked 97th overall. I was glad to see Forever Evil Argus nearby in sales.
Those sales numbers look bad in comparison to Supergirl #25 which sold 25377. That means Supergirl #26 was down 9% in sales. But Supergirl #25 did get a bump from 'Krypton Returns' (as crazy as that sounds).
But if you compare sales to Supergirl #24 (which sold 23321), it looks more like a natural attrition of sales.
Still, we are approaching the dreaded 20K 'cancellation watch' level. And the fact that the title hasn't had a Scribblenaut variant, a Steampunk variant, or an Annual, it makes me worry that the book is something of an afterthought for DC. It makes the Red Lantern storyline that much more interesting to watch closely.